Project
Quantitative pre- and postnatal magnetic resonance imaging in the diagnosis of congenital disorders of brain myelination. RFBR project. Agreement No. 19-75-20142. Head – Yarnykh V.L.
Aim of the project:
Search and clinical application of new non-invasive quantitative biomarkers of maturation and damage to brain matter in the process of pre- and post-natal development of the central nervous system for the diagnosis, prevention, and control of treatment of socially significant neurological diseases of childhood.
Expected results:
1. A fundamentally new unified technology for the clinical assessment of myelination of the brain of the child and the fetus, providing high accuracy and reproducibility of measurements using widespread Philips tomographs.
2. An electronic atlas of myelination of the brain of the child and the fetus, containing averaged normal MPF maps for specific age categories, which will become a unique tool for fundamental and clinical neuroscience.
3. Fundamental knowledge of the quantitative trajectories of myelination of the anatomical structures of the human brain in the process of pre- and post-natal development.
4. Fundamental knowledge about the relationship of cerebral myelination disorders and developmental delays of the child and fetus.
5. Practical recommendations on the use of MPF mapping as a diagnostic and prognostic method for assessing myelination in pediatric and prenatal radiation diagnostics, based on a large-scale clinical study.
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Project
The study of neuroglial interactions in the restoration of nervous tissue after modeling of ischemic stroke in rats. RFBR project. Agreement No. 19-315-90119. Head – Khodanovich M.Yu.
Aim of the project:
Identification of features of neuroglial interactions in the restoration of nervous tissue after modeling of ischemic stroke in rats.
Expected results:
Structural changes in the myelin sheaths, neuroglial intercellular contacts will be revealed.
Changes in brain cytoarchitectonics in the area of ischemic lesion will be revealed.
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Project
Non-invasive imaging of natural and induced neurogenesis. RSF project. Agreement No. 18-15-00229. Head – Khodanovich M.Yu.
Aim of the project:
The development of highly specific methods based on genetic engineering for intravital visualization of brain regeneration processes for fundamental neurobiology and preclinical studies.
Expected results:
A non-invasive neurogenesis imaging technique will provide a new tool for obtaining fundamental knowledge about the mechanisms, dynamics and regulators of recovery processes in brain pathologies.
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Project:
Non-invasive quantitative charting of myelination of the gray matter of the brain. Russian Science Foundation. Head in charge Vasiliy L. Yarnykh The project aims to identify biomarkers for diagnosing a number of neurodegenerative diseases of Alzheimer’s disease and Parkinson’s disease.
Partner:
University of Washington
(development of a method of mapping the brain myelin).
Results
the method of diagnosing neurodegenerative diseases.